Optimal Dosage Guide for a Combined Sermorelin & Ipamorelin Therapy
Sermorelin and Ipamorelin are two peptides that work together to stimulate the body’s natural production of growth hormone in a highly targeted way. When combined into a stack they offer an array of benefits for both physical performance and overall health, while keeping side-effects at a minimum compared with more aggressive synthetic analogues.
Sermorelin/Ipamorelin Blend Dosage
A common starting protocol for most healthy adults is to inject 0.25 mg (250 µg) of Sermorelin mixed with 0.25 mg of Ipamorelin, giving a total dose of 500 µg per injection. This blend is usually administered once daily in the morning, preferably on an empty stomach, to take advantage of the natural circadian rhythm that peaks growth hormone secretion early in the day. The dosage can be increased gradually by 0.05 mg increments for each peptide up to a maximum of 1 mg total if the user desires higher stimulation and their body tolerates it well. The peptides are typically dissolved in sterile water or saline, reconstituted with a syringe, and injected subcutaneously into the abdomen or thigh.
For those focusing on muscle growth or recovery, a slightly larger dose such as 0.5 mg of each peptide (1 mg total) can be used, but it is advisable to monitor hormone levels and adjust accordingly. Because Sermorelin has a short half-life, it is sometimes administered twice daily in high-intensity training regimes: one injection pre-workout at around 7 am and another post-workout around 4 pm. Ipamorelin’s longer action makes it suitable for a single morning dose, but if split dosing is chosen the second injection should be no later than mid-afternoon to avoid interference with nighttime sleep cycles.
What is Sermorelin?
Sermorelin is a synthetic peptide that mimics the natural growth hormone-releasing hormone (GHRH) produced by the hypothalamus.
Sermorelin and Ipamorelin are two peptides that work together to stimulate the body’s natural production of growth hormone in a highly targeted way. When combined into a stack they offer an array of benefits for both physical performance and overall health, while keeping side-effects at a minimum compared with more aggressive synthetic analogues.
Sermorelin/Ipamorelin Blend Dosage
A common starting protocol for most healthy adults is to inject 0.25 mg (250 µg) of Sermorelin mixed with 0.25 mg of Ipamorelin, giving a total dose of 500 µg per injection. This blend is usually administered once daily in the morning, preferably on an empty stomach, to take advantage of the natural circadian rhythm that peaks growth hormone secretion early in the day. The dosage can be increased gradually by 0.05 mg increments for each peptide up to a maximum of 1 mg total if the user desires higher stimulation and their body tolerates it well. The peptides are typically dissolved in sterile water or saline, reconstituted with a syringe, and injected subcutaneously into the abdomen or thigh.
For those focusing on muscle growth or recovery, a slightly larger dose such as 0.5 mg of each peptide (1 mg total) can be used, but it is advisable to monitor hormone levels and adjust accordingly. Because Sermorelin has a short half-life, it is sometimes administered twice daily in high-intensity training regimes: one injection pre-workout at around 7 am and another post-workout around 4 pm. Ipamorelin’s longer action makes it suitable for a single morning dose, but if split dosing is chosen the second injection should be no later than mid-afternoon to avoid interference with nighttime sleep cycles.
What is Sermorelin?
Sermorelin is a synthetic peptide that mimics the natural growth hormone-releasing hormone (GHRH) produced by the hypothalamus.